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PR segment depression may indicate atrial injury or pericarditis.
Why males consistently developed ST segment depression following isoproterenol administration and females did not remains unanswered.
Those patients with ST segment depression would be people now regarded as having non-Q wave infarction.
The mortality rate in these patients with ST segment depression, both in the control and in the treated groups, is considered high at approximately 18%.
Finally, there remains a question about the patients who present with significant ST segment depression, probably indicative of a subendocardial myocardial infarction, but which might be unstable angina.
At this point there may be signs of ventricular strain pattern (ST segment depression and T wave inversion) on the EKG, suggesting subendocardial ischemia.
ST segment depression may be determined by measuring the vertical distance between the patient's trace and the isoelectric line at a location 2-3 millimeters from the QRS complex.
ST segment depression, suggestive of acute subendocardial ischemia, was consistently observed in C57BL/6 male mice but not in all female mice immediately following administration of isoproterenol.
ST segment depression and T wave inversion in right precordial leads is usually seen in severe RVH such as in pulmonary stenosis and pulmonary hypertension.
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