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Together, these three discrimination steps enable replication fidelity of less than one mistake for every 10 nucleotides added.
If we have a replication fidelity of Q approaching 0, then the equilibrium concentrations will be roughly .
Lower concentrations Mg will increase replication fidelity, while higher concentrations will introduce more mutations.
One of Taqs drawbacks is its lack of 3' to 5' exonuclease proofreading activity resulting in relatively low replication fidelity.
The small size of RNA viruses has been proposed to be locked into a three part relation between replication fidelity, genome size and genetic complexity.
The majority of RNA viruses lack an RNA proofreading facility which limits their replication fidelity and hence the genome size.
Pol V's strict regulation stems from its poor replication fidelity, Pol V is highly mutagenic and it is used as a last resort in DNA repair mechanisms.
This increase in errors is most likely the direct result of the mutations identified within the pol coding region and suggests that this virus may indeed possess a Pol defect in replication fidelity.
ORFs 1a and 1b contain six replicase domains, as well as the 3'-5' exoribonuclease (ExoN) that controls RNA replication fidelity and a 2'-O-methyltransferase, both of which are found in larger nidoviruses.
"The Ascent(R) XJ Trainer(TM) offers us the outstanding replication fidelity, economic savings and flexibility we need to continue being the leader in MPL training for today's airlines", said Anna Kjaer, Center Air's Chief Ground Instructor and Operations Manager.