nuclear receptor

He is particularly interested in nuclear receptors, which are master regulators of metabolism.

TR2 is a member of the nuclear receptor family of transcription factors.

Below is a brief selection of key events in the history of nuclear receptor research.

Nuclear receptor related 1 protein has been shown to interact with:

Numerous other enzyme activities have been reported among the 300 known coactivators for nuclear receptors.

There are 270 nuclear receptors in the nematode C. elegans alone.

As discussed below, nuclear receptors may be classified according to either mechanism or homology.

The following is a list of the 48 known human nuclear receptors categorized according to sequence homology.

They bind to nuclear receptors in the cell nucleus for genomic actions.

Steroid receptors of the nuclear receptor family are all transcription factors.

Comparatively little is known about ear-2, but it has been shown to function as a coregulator of other nuclear receptors.

As a consequence, nuclear receptors play key roles in both embryonic development and adult homeostasis.

Further, human drug-metabolizing enzymes are typically activated through the engagement of nuclear receptors.

Nuclear receptors are modular in structure and contain the following domains:

It may function as an integrator of transcription repression and nuclear receptor signaling.

Depending on their mechanism of action and subcellular distribution, nuclear receptors may be classified into at least two classes.

Retinoids can act on retinoid nuclear receptors and thus regulate transcription.

Nuclear receptors bind to coactivators in a ligand-dependent manner.

The ERRs are members of the orphan nuclear receptor family.

The A-B domain is highly variable in sequence between various nuclear receptors.

Accordingly, nuclear receptors may be subdivided into the following four mechanistic classes:

Like alpha, beta is a nuclear receptor, based in the heart of the cell and designed to fiddle periodically with its genetic material.

It binds to nuclear receptors that regulates gene transcription.

Approximately 10% of currently prescribed drugs directly target the nuclear receptor class of transcription factors.

Although the specific functions of this nuclear receptor have not been fully characterized yet, some roles emerge from the literature on the mouse gene.