membrane cofactor protein , MCP (skrót)

The gene for membrane cofactor protein is the next target.

Mutations in the complement regulators factor H and membrane cofactor protein have been associated with atypical haemolytic uraemic syndrome.

Membrane cofactor protein (MCP or CD46)

The hyperacute rejection reaction is known to be mediated by complement which in itself is regulated by a family of membrane glycoproteins including decay-accelerating factor (DAF) and membrane cofactor protein.

CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene.

The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane cofactor protein), or is occasionally due to acquired neutralizing autoantibody inhibitors of these complement system components, for example anti-factor H antibodies.

A rare subset of this disease (referred to as atypical haemolytic uraemic syndrome, aHUS), has been strongly linked to mutations in genes of the complement system (including factor H, factor I and membrane cofactor protein), with the factor H mutations being the most numerous.