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Damage to the fronto-striatal system may underlie cognitive problems including executive function and sequencing tasks.
Another area of impairment due to fronto-striatal dysfunction is in the area of emotion recognition.
The authors suggested that fronto-striatal abnormalities related to HIV may underlie these impairments.
A study by Melrose et al. (2008) examined the integrity of the fronto-striatal circuitry that underlies executive functioning in HIV.
HIV is associated with pathological changes in mainly subcortical and fronto-striatal areas of the brain, including the basal ganglia, deep white matter, and hippocampal regions.
Additionally, the anterior parietal activity showed a relationship with caudate functioning, which implicates a compensatory mechanism set forth when damage to the fronto-striatal system occurs .
Studies have shown that patients exhibit cognitive deficits consistent with dysfunction of fronto-striatal circuits including associated parietal areas, the latter of which may account for observed deficits in visuospatial function.
People with social reward dependence personalities were also seen to have brains with far less tissue in the fronto-striatal section of the brain (e.g. damage to the fronto-striatal area is often linked to autism and schizophrenia).
Preschoolers' performance on delayed gratification tasks correlates with their adolescent performance on tasks designed to measure similar constructs and processing, which parallels the corresponding development of willpower and the fronto-striatal circuit (neural pathways that connect the frontal lobe to other brain regions).
Słownik terminów anatomicznych