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It functions in the cornified cell envelope formation.
Loricrin is a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells.
The Stratum corneum of people with dark or heavily tanned skin is more condensed and contains more cornified cell layers than in lightly pigmented humans.
These hard, integumentary structures are formed by intercellular cementing of fibers formed from the dead, cornified cells generated by specialized beds deep within the skin.
TG5 is strongly expressed in the epidermal granular cells, where it cross-links a variety of structural proteins in the terminal differentiation of the epidermis to form the cornified cell envelope.
Słownik biologiczny