anaphase promoting complex

However, the most important interaction of Cdc20 is with the Anaphase Promoting Complex.

This degradation occurs in late mitosis and is regulated by the anaphase promoting complex (APC).

An important regulatory event during G1 is the inactivation of the anaphase promoting complex (APC-Cdh1).

After checkpoint deactivation and during the normal anaphase of the cell cycle, the anaphase promoting complex is activated through decreasing MCC activity.

Geminin first appears in S-phase and is degraded at the metaphase-anaphase transition, possibly through ubiquination by anaphase promoting complex (APC).

His lab discovered and purified many of the components involved in cell cycle progression, including anaphase promoting complex (APC), the complex that ubiquitinates cyclin B.

Geminin was originally identified as an inhibitor of DNA replication and substrate of the anaphase promoting complex (APC).

The anaphase promoting complex associated to Cdc20 (APC/C-cdc20) cleaves the securin (anaphase inhibitor), which holds the sister chromatids together.

Geminin levels drop at the metaphase / anaphase transition of mitosis when it is degraded by the Anaphase Promoting Complex (APC/C).

The spindle assembly checkpoint inhibits the activity of the anaphase promoting complex by preventing degradation of downstream effectors, which otherwise lead to anaphase onset and exit from mitosis.

The SAC stops the cell cycle by negatively regulating CDC20, thereby preventing the activation of the polyubiquitylation activities of anaphase promoting complex (APC).

To the best of current knowledge its most important function is to activate the anaphase promoting complex (APC), a large 11-13 subunit complex that initiates chromatid separation and entrance into anaphase.

Earlier cell cycle checkpoints such a post-restriction point check between G1 phase and S phase similarly involve proteasomal degradation of cyclin A, whose ubiquitination is promoted by the anaphase promoting complex (APC), an E3 ubiquitin ligase.

Bub3 and its related proteins that form the Spindle Assembly Checkpoint (SAC) inhibit the action of the Anaphase Promoting Complex (APC), preventing early anaphase entry and mitotic exit; this serves as a mechanism for the fidelity of chromosomal segregation.