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A deficiency of alpha granules is known as grey platelet syndrome.
It may involve the alpha granules or the dense granules.
Platelet alpha2-antiplasmin is located in the alpha granules.
Alpha granules may be missing from the platelets.
In platelets, the term "alpha granules" is used to describe granules containing several growth factors.
The alpha granules express the adhesion molecule P-selectin and CD63.
The granules of platelets are classified as dense granules and alpha granules.
The only parallel organelle in physiology is the alpha granule of platelets, which also contains vWF.
There is an absence of lysosomes in the fibroblasts and depletion of alpha granules in their platelets.
Biochemical studies of two patients with the grey platelet syndrome: Selective deficiency of platelet alpha granules.
The platelets collected in PRP are activated by the addition of thrombin and calcium chloride, which induces the release of these factors from alpha granules.
Alpha granules (containing P-selectin, platelet factor 4, transforming growth factor-β1, platelet-derived growth factor, fibronectin, B-thromboglobulin, vWF, fibrinogen, and coagulation factors V and XIII).
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