Michael reaction

The Michael reaction can occur under neutral conditions through an enamine.

Another example is the Michael reaction of indole and nitroethylene.

New monomer adds to the initiator and to the active growing chain in a Michael reaction.

Sesquiterpene lactones, found in many plants, can react with other molecules via a Michael reaction.

This encouraged a Michael reaction leading to alkylation of a thiol group in the enzyme's active site.

In particular, it catalyzes the Michael reaction and the Mukaiyama-aldol reaction.

The Michael reaction involves conjugate additions of enolates to conjugated carbonyls.

Arthur Michael is remembered today primarily for the Michael reaction, also called the Michael addition.

The reaction is also used in combination with the Michael reaction in the synthesis of γ-keto-carbonyls such as:

It has been employed in an asymmetric Michael reaction with cyclohexenone and dimethyl malonate:

During a Michael reaction or a Claisen rearrangement, camphorsultam is able to confer a great deal of stereoselectivity.

The dendrimer is assembled from a multifunctional core, which is extended outward by a series of reactions, commonly a Michael reaction.

A well-known Michael reaction is the synthesis of warfarin from 4-hydroxycoumarin and benzylideneacetone first reported by Link in 1944:

Michael reaction (villalstonine)

As a representative example, Deng and coworkers have developed a thiourea-amine catalyst capable of promoting stereoselective Michael reactions.

In addition when Y-Z is an active hydrogen compound the reaction is known as a Michael reaction.

Common reactions include nucleophilic conjugate addition with organocopper reagents, Michael reactions and Robinson annulations.

Basic catalysts have been used for hydrogenations, the migration of double bonds, in the Meerwein-Ponndorf-Verley reduction, the Michael reaction, and many other reactions.

Hydrocyanation of unsaturated carbonyl compounds is a special case of the Michael reaction which can lead to β-cyanoketones, β-cyano-cyanohydrins, or vinyl cyanohydrins.

A Robinson annulation involves a α,β-unsaturated ketone and a carbonyl group, which first engage in a Michael reaction prior to the aldol condensation.

She also was a student of Tufts, and later Harvard, organic chemist Arthur Michael (known for the Michael reaction), who she subsequently married.

Cyclohexenone 1 was reacted with dimethyl malonate 2 in an asymmetric Michael reaction using AlLibis(binaphthoxide) to form chiral diester 3.

In more specialized organic synthesis, nitromethane serves as a Michael donor, adding to α,β-unsaturated carbonyl compounds via 1,4-addition in the Michael reaction.

In one study, the Nazarov cyclization is paired with a Michael reaction using an iridium catalyst to initiate nucleophilic conjugate addition of the enolate to nitrostyrene.

The mesityl oxide formed can react further with acetone via a Michael reaction and subsequent intramolecular aldol condensation to eventually obtain the six-membered ring of isophorone.