B cell receptors

Following engagement of the B cell receptors, Lyn undergoes rapid phosphorylation and activation.

These cells have receptors that are similar to B cell receptors, and each cell recognizes only a few class II-peptide combinations.

In humans, the cell surface is bare around the B cell receptors for several hundred nanometers, which further isolates the BCRs from competing influences.

The immature B cells whose B cell receptors (BCRs) bind too strongly to self antigens will not be allowed to mature.

PTPN22 affects the responsiveness of T and B cell receptors, and mutations are associated with increases or decreases in risks of autoimmune diseases.

The mutation Arg620Trp disrupts binding to Csk, alters the responsiveness of T and B cell receptors, and is associated with autoimmune diseases.

Once a T cell recognizes a peptide within an MHC class II molecule, it can stimulate B-cells that also recognize the same molecule in their B cell receptors.

Antigenicity is the ability of a chemical structure (referred to as an antigen) to bind specifically with a group of certain products that have adaptive immunity: T cell receptors or antibodies (a.k.a. B cell receptors).

A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements (antigens) and allows the immune system to adapt its response to new threats during the lifetime of an organism.

Somatic hypermutation, thus, makes the B cell receptors and the soluble antibodies in subsequent encounters with antigens, more inclusive in their antigen recognition potential of "altered" epitopes, apart from bestowing greater specificity for the antigen that induced proliferation in the first place.